GLP-1 Drugs for Weight Loss & Diabetes: Here’s How It Works
Each article on the fitterfly website is a labor of love, reviewed by a team of certified medical experts specializing in various fields like Diabetology, Nutrition, Physiotherapy, Psychology.
They carefully examine all references and facts to provide up-to-date and reliable information, aiming to break myths and empower you in your health journey.
Meet Our Reviewing Team
Dr. Vidya Jaydeep Walinjkar
Dr. Vidya Walinjkar has 14 yrs of experience as a diabetologist and physician. She currently works as a Consulting Diabetologist and Program Consultant for Type 2 diabetes members at Fitterfly.
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GLP-1 medications have taken the health world by storm – from doctor’s clinics to red carpets in Bollywood and Hollywood. They’re often talked about as game-changers for diabetes management and weight loss. But what’s the real story?
Are they safe? Do they actually work? And if our body already produces GLP-1, why do we need more from outside?
Let’s find out.
What is GLP-1?
GLP-1 stands for glucagon-like peptide-1, a naturally occurring hormone in your gut. It helps regulate blood sugar by stimulating insulin release and reducing appetite.
In simple words, it tells your brain: “I’m full, stop eating,” and helps manage how your body uses and stores glucose.
How Does GLP-1 Work?
GLP-1 receptor agonists (like semaglutide) are medications that mimic the action of natural GLP-1 in your body. Here’s what they do:
- Help your body release insulin when your blood sugar is high
- Reduce another hormone called glucagon that usually increases blood sugar
- Slow down digestion, so you feel full for longer
- Send signals to your brain to curb hunger and reduce cravings
This multi-action approach is what makes GLP-1 drugs helpful in both type 2 diabetes and weight management
If Our Body Already Makes GLP-1, Why Take It From Outside?
Great question. And this is where it gets interesting.
In many people with obesity or type 2 diabetes, GLP-1 levels are lower or not as effective. Injectable GLP-1 agonists give your body that stronger, longer-lasting signal to:
- Reduce appetite
- Manage blood glucose
- Support gradual, sustainable weight loss
Who is GLP-1 Recommended For?
GLP-1 drugs are primarily recommended for:
- Adults with type 2 diabetes who aren’t seeing results from oral medications and need better blood sugar control
- People with obesity or with a BMI over 30 (with or without diabetes) seeking medical weight management
Doctors may also consider GLP-1 RAs for patients with cardiovascular risk factors, as some of these drugs have shown heart-protective benefits.
How Does GLP-1 Help with Weight Loss?
GLP-1 RAs help with weight loss in several ways:
- Reduce appetite: They slow stomach emptying and signal the brain to feel full sooner.
- Lower calorie intake: By curbing hunger, people naturally eat less.
- Stabilises blood sugar: They enhance insulin sensitivity and reduce blood sugar spikes.
Clinical trials show that people without diabetes can lose 6–17% of their body weight on GLP-1 drugs, while those with diabetes typically lose 4–6%. Semaglutide and liraglutide are among the most effective, with semaglutide often leading to greater weight loss.
Are There Any Side Effects of GLP-1?
Yes, like all medications, GLP-1 RAs can cause side effects. The most common are:
- Nausea
- Vomiting
- Diarrhea
- Constipation
Most side effects are mild and tend to improve over time. However, higher doses can increase the risk of gastrointestinal issues. Rare but serious risks include pancreatitis and gallbladder problems, so regular medical supervision is essential.
Is GLP-1 Safe? What Experts Say
GLP-1 RAs are clinically approved and have a strong safety record when used as prescribed. They are not a shortcut or “magic bullet” – they work best as part of a comprehensive plan that includes healthy eating, regular physical activity, and ongoing medical supervision.
Even celebrities who’ve made headlines for dramatic transformations haven’t relied on GLP-1 alone. It’s part of a well-rounded plan.
For example, one of our members (name withheld for privacy) combined semaglutide with a balanced diet and regular exercise, achieving a 10% weight loss over six months and improved blood sugar control.
“I finally feel in control of my health again,” she shared.
What Are the Popular GLP-1 Drugs in India?
As of now, here are some of the top GLP-1 options available or coming soon:
| Brand Name | Generic Name | Status in India |
| Ozempic | Semaglutide | Not easily available in India* |
| Rybelsus | Oral Semaglutide | Available |
| Mounjaro | Tirzepatide (GLP-1 + GIP) | Launched |
| Wegovy | Semaglutide (high dose) | Coming soon |
*Ozempic is currently not easily available in India, and other brands may be accessible only in select cities or hospitals. Plus, they can be expensive and require a prescription.
Indian pharma companies are also working on cost-effective versions, making it more accessible in the near future.
Who Should Not Take GLP-1?
GLP-1 RAs are not suitable for everyone. They should generally be avoided in:
- People with type 1 diabetes
- People with a history of medullary thyroid cancer (personal or family history)
- Those with a history of pancreatitis
- Pregnant or breastfeeding women
Always consult your doctor before starting any new medication and we highly recommend Dr. Vidya Walinjkar, our in-house Diabetologist with 17 + years of experience.
How We At Fitterfly Can Help?
If you’re someone struggling with diabetes, weight, or related conditions, GLP-1 might be worth exploring – but ONLY and ONLY under expert guidance.
At Fitterfly, we’ve seen firsthand how powerful this therapy can be – when combined with the right support system.
We’ve helped thousands of people take charge of their health and we’re ready to help you too.
Call us at 08068507599 to know more or simple avail a 1-on-1 consultation with our highly experienced in-house specialist, Dr. Vidya Walinjkar.
This blog provides general information for educational and informational purposes only and shouldn't be seen as professional advice.
Frequently Asked Questions
Is GLP-1 safe for long-term use?
The long-term use of GLP-1 should be decided case by case under medical guidance only. That said, regular monitoring and dose adjustments are essential.
Will I gain weight again after stopping GLP-1?
Yes, you will gain weight after stopping GLP-1. GLP-1 helps regulate appetite. Once you stop, those signals may fade, leading to increased hunger. That’s why a supportive plan with nutrition, exercise, and coaching is critical during and after treatment.
Can I take GLP-1 without diabetes?
Always consult a doctor before starting any medicine. GLP-1 is also approved for people without diabetes who are dealing with obesity or weight-related conditions. However, it’s not meant for casual or cosmetic use.
Is GLP-1 addictive?
No, GLP-1 drugs are not addictive. They work by mimicking a natural hormone in your body. However, they should never be self-administered or taken for unsupervised weight loss. Consistent check-ins with your healthcare provider are key to safe use.
